RESEARCH ARTICLES & REVIEWS
Articles marked OA are open access and may be freely viewed at the publisher's website. Other articles require a subscription to view at the publisher; OA versions of these articles are available either as pre-prints on bioRxiv (2016 onwards) or via a link marked 'Free PDF' (provided according to the terms of each publisher's copyright agreement - most are non-typeset versions of the accepted article).
Paramalingam Y, Arjmandi H, Harrison F, Schiller T, Noel A (preprint) Anisotropic diffusion model of communication in 2D biofilm. arXiv. doi.org/10.48550/arXiv.2408.07626
Piazza AM, Dasanayaka H, Martins C, Saalbach G, Trampari E, Webber M, Harrison F, Malone J (submitted) BatR: A novel regulator of antibiotic tolerance in Pseudomonas aeruginosa biofilms. bioRxiv 2024.04.17.589660 DOI: https://doi.org/10.1101/2024.04.17.589660
Simm C, Lee T-H, Weerasinghe H, Walsh D, Nakou I, Shankar M, Tse WC, Zhang Y, Inman R, Mulder R, Harrison F, Aguilar M-I, Challis G, Traven A (in press) Gladiolin produced by pathogenic Burkholderia synergizes with amphotericin B through membrane lipid rearrangements. Accepted for publication in mBio
Walsh D, Parmenter C, Bakker SE, Lithgow T, Traven A, Harrison F (2024) A new model of endotracheal tube biofilm identifies combinations of matrix-degrading enzymes and antimicrobials able to eradicate biofilms of pathogens that cause ventilator-associated pneumonia. Microbiology 170:001480 (From publisher, OA)
Walsh, D, Bevan, J, Harrison, F (2024) How does airway surface liquid composition vary in different pulmonary diseases, and how can we use this knowledge to model microbial infections? Microorganisms 12:732 (From publisher, OA)
Darby EM, Moran RA, Holden E, Morris T, Harrison F, Clough B, McInnes RS, Schneider L, Frickel EM, Webber MA, Blair JMA (2024) Differential development of antibiotic resistance and virulence between Acinetobacter species. mSphere 9:e00109-24 (From publisher, OA)
Concilio M, Garcia Maset R, Pasquina Lemonche L, Kontrimas V, Song J-I, Rajendrakumar SK, Harrison F, Becer R & Perrier S (2023) Mechanism of action of oxazoline-based antimicrobial polymers against S. aureus: in vivo antimicrobial activity evaluation. Advanced Healthcare Materials 2023:2301961 (From publisher, OA)
Harrison F, Blower A, de Wolf C & Connelly E (2023) Sweet and sour synergy: exploring the antibacterial and antibiofilm activity of acetic acid and vinegar combined with medical-grade honeys. Microbiology 169:001351 (From publisher, OA) (Article in The Times)(Article in the New York Post)(Article in Scientific American)(Podcast from Drug Discovery News)
Garcia Maset R, Hapeshi A, Lapage J, Harrington Niamh E, Littler Jenny L, Perrier S & Harrison, F (2023) Combining SNAPs with antibiotics shows enhanced synergistic efficacy against S. aureus and P. aeruginosa biofilms. npj Biofilms and Microbiomes. 9:36 (From publisher, OA)
Bruce J, Oyedemi B, Parsons N & Harrison F (2022) Phase 1 safety trial of a natural product cocktail with antibacterial activity in human volunteers. Scientific Reports. 12:19656. DOI: 10.1038/s41598-022-22700-4 (From publisher, OA)
Harrington, NE, Allen, F, Garcia Maset, R & Harrison, F (2022) Pseudomonas aeruginosa transcriptome analysis in a cystic fibrosis lung model reveals metabolic changes accompanying biofilm maturation and increased antibiotic tolerance over time. bioRxiv 2022.06.30.498312 (preprint)
Garcia Maset, R, Hapeshi, A, Hall, S, Dalgliesh, R, Harrison, F & Perrier, S (2022) Evaluation of the antimicrobial activity in host-mimicking media and in vivo toxicity of antimicrobial polymers as functional mimics of AMPs. ACS Applied Materials & Interfaces 14:32855 (From publisher, OA)
Harrison F, Furner-Pardoe J, Connelly E (2022) An assessment of the evidence for antibacterial activity of stinging nettle (Urtica dioica) extracts. Access Microbiology 4:000336 (From publisher, OA)
Harrington, NE, Littler, JL & Harrison, F (2022) Transcriptome analysis of Pseudomonas aeruginosa biofilm infection in an ex vivo pig model of the cystic fibrosis lung. Applied and Environmental Microbiology 88:e01789-21 (From publisher, OA)
O’Toole GA, Crabbé A, Kümmerli R, LiPuma JJ, Bomberger JM, Davies JC, Limoli D, Phelan VV, Bliska JB, DePas WH, Dietrich LE, Hampton TH, Hunter R, Khursigara CM, Price-Whelan A, Ashare A, Cramer RA, Goldberg JB, Harrison F, Hogan DA, Henson MA, Madden DR, Mayers JR, Nadell C, Newman D, Prince A, Rivett DW, Schwartzman JD, Schultz D, Sheppard DC, Smyth AR, Spero MA, Stanton BA, Turner PE, Gast Cvd, Whelan FJ, Whitaker R, Whiteson K. (2021) Model systems to study the chronic, polymicrobial infections in cystic fibrosis: current approaches and exploring future directions. mBio. 12:e01763-21 (From publisher, OA)
O'Brien, TJ, Hassan, MM, Harrison, F & Welch M. (2021) An in vitro model for the cultivation of polymicrobial biofilms under continuous-flow conditions. F1000Research 10:801 DOI: doi.org/10.12688/f1000research.55140.1 (From publisher, OA)
Harrington, NE, Sweeney, E, Alav, I, Allen, F, Moat, J & Harrison, F (2021) Antibiotic efficacy testing in an ex vivo model of Pseudomonas aeruginosa and Staphylococcus aureus biofilms in the cystic fibrosis lung. Journal of Visuaized Experiments 167:e62187. (From publisher, OA)
Harrison, F & Smyth, AR (2021) Professor Pangloss and the pangenome: Does Staphylococcus aureus have the best of all possible worlds? American Journal of Respiratory and Critical Care Medicine, AOP. (From publisher, OA)
Sweeney, E, Hassan, MM, Harrington, NE, Smyth, AR, Hurley, MN, Tormo-Mas, MA & Harrison, F (2021) An ex vivo cystic fibrosis model recapitulates key clinical aspects of chronic Staphylococcus aureus infection. Microbiology 167:000987 (From publisher, OA; Conference poster published in Access Microbiology, OA) Editor's choice for this issue of Microbiology!
Sweeney, E, Sabnis, A, Edwards, AM & Harrison, F (2020) Effect of host-mimicking medium and biofilm growth on the ability of colistin to kill Pseudomonas aeruginosa. Microbiology 166:1171 (From publisher, OA) Editor's choice for this issue of Microbiology!
Anonye, BO, Nweke, V, Furner-Pardoe, J, Gabrilska, R, Rafiq, A, Ukachukwu, F, Bruce, J, Lee, C, Unnikrishnan, M, Rumbaugh, KP, Snyder, LA & Harrison, F (2020) The safety profile of Bald's eyesalve for the treatment of bacterial infections. Scientific Reports 10:17513 (From publisher, OA)
Hassan, MM, Harrington, NE, Sweeney, E & Harrison, F (2020) Predicting antibiotic-associated virulence of Pseudomonas aeruginosa using an ex-vivo lung biofilm model. Frontiers in Microbiology 11:2175 (From publisher, OA)
Furner-Pardoe, J, Anonye, BO, Cain, R, Moat, J, Ortori, CA, Lee, C, Barrett, DA, Corre, C & Harrison, F (2020) Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients. Scientific Reports 10:12687 (From publisher, OA)
[Conference poster] Crealock-Ashurst, B, Harrison, F & Sweeney, E (2020) Assessing acute and chronic Staphylococcus aureus growth and virulence in an ex vivo model of cystic fibrosis lung infection. Access Microbiology 2:255 (From publisher, OA)
Harrington, NE, Sweeney, E & Harrison, F (2020) Building a better biofilm - formation of in vivo-like biofilm structures by Pseudomonas aeruginosa in a porcine model of cystic fibrosis lung infection. Biofilm 2:100024 (From publisher, OA)
Connelly, E, del Genio, CI & Harrison, F (2020) Datamining a medieval medical text reveals patterns in ingredient choice that reflect biological activity against the causative agents of specified infections. mBio 11:e03136-19 (From publisher, OA)
Harrison, F & Connelly, E (2019) Could Medieval Medicine Help the Fight Against Antimicrobial Resistance? In Chris Jones, Conor Kostick, Klaus Oschema (eds.), Making the Medieval Relevant: How Medieval Studies Contribute to Improving our Understanding of the Present (pp. 113–134). Berlin, Boston: De Gruyter. (From publisher, OA)
Brockhurst, MA, Harrison, F, Veening, J-W, Harrison, E, Blackwell, G, Iqbal, Z & Maclean, C (2019) Assessing evolutionary risks of resistance for new antimicrobial therapies. Nature Ecology & Evolution 3:515 (From publisher) (ReadCube, OA)
Chen, F, Moat, J, Daniel McFeely, D, Clarkson, G, Hands-Portman, IJ, Furner-Pardoe, JP, Harrison, F, Dowson, CG & Sadler, PJ (2018) Biguanide complexes with potent antimicrobial activity. Journal of Medicinal Chemistry 61:7330 (From publisher, OA)
Davies, SK, Fearn, S, Allsopp, LP, Harrison, F, Ware, E, Diggle, SP, Filloux, A, McPhail, DS & Bundy, JG (2017) Visualizing antimicrobials in bacterial biofilms: three-dimensional biochemical imaging using TOF-SIMS. mSphere, 2017. 2:e00211-17 (From publisher, OA)
Harrison, F, McNally, A, da Silva, AC, Heeb, S & Diggle, SP (2017) Optimised chronic infection models demonstrate that siderophore “cheating” in Pseudomonas aeruginosa is context specific. ISME Journal 11:2492 (From publisher, OA)
Mund, A, Diggle, SP & Harrison, F (2017) The fitness of Pseudomonas aeruginosa quorum sensing signal cheats is influenced by the diffusivity of the environment. mBio 8:00353-17 (From publisher, OA)
Popat, R, Harrison, F, McNally, L, Williams, P & Diggle, SP (2017) Environmental modification via a quorum sensing molecule influences the social landscape of siderophore production. Proceedings B 284:20170200 (From publisher, OA)
Granato, ET, Harrison, F, Kümmerli, R & Ross-Gillespie, A (2016) When is a bacterial "virulence factor" really virulent? Frontiers in Microbiology 7:1952 (From publisher, OA)
Harrison, F & Diggle, SP (2016) An ex vivo lung model to study bronchioles infected with Pseudomonas aeruginosa biofilms. Microbiology 162:1755 (From publisher)
Ruparell, A, Dubern, JF, Ortori, CA, Harrison, F, Halliday, NM, Emtage, A, Ashawesh, M, Laughton, CA, Diggle, SP, Williams, P, Barrett, DA & Hardie, KR (2016) The fitness burden imposed by synthesising quorum sensing signals. Scientific Reports 6:33101. (From publisher, OA)
Harrison, F, Roberts, AEL, Rumbaugh, KP, Gabrilska, R, Lee, C & Diggle, SP (2015) A 1,000-year-old antimicrobial remedy with anti-Staphylococcal activity. mBio 6:e01129-15. (From publisher, OA). This work received a huge amount of press attention when I spoke about it at an SGM conference in spring 2015, including features on BBC Radio 4's Today and on Sky News. Some of my favourite print articles came courtesy of New Scientist, National Geographic, medievalists.net and the Science Viking blog.
Popat, R, Pollitt, EJG, Harrison, F, Naghra, H, Hong, K-W, Chan, K-G, Griffin, AS, Williams, P, Brown, SP, West, SA & Diggle, SP (2015) Conflict of interest and signal interference lead to the breakdown of honest signalling. Evolution 69:2371. (From publisher, OA)
Darch, SE, McNally, A, Harrison, F, Corander, J, Barr, HL, Paszkiewicz, K, Holden, S, Fogarty, A, Crusz, SA & Diggle, SP (2015) Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection. Nature Scientific Reports 5:7649. (From publisher, OA)
Pollitt, EJG, Harrison, F & Diggle, SP (2015) Quorum sensing and social interactions during infection Microbe 10:17 (From Publisher)
Haddad, ADM, Harrison, F, Norman, T & Lau, JYF (2014) Adolescent and adult risk-taking in virtual social contexts. Frontiers in Psychology 5:1476 (From Publisher)
Harrison, F, Muruli, A, Higgins, S & Diggle, S (2014) Development of an ex vivo porcine lung model for studying growth, virulence and signalling of Pseudomonas aeruginosa. Infection and Immunity 82:3312. (From publisher, OA)
Barta, Z, Székely, T, Liker, A & Harrison, F (2014) Social role specialisation promotes cooperation between parents. American Naturalist 183:747. (From publisher, OA). I gave a talk about this work at the 2013 ESEB meeting, which you can watch on YouTube.
Moore, D, Wigby, S, English, S, Wong, S, Székely, T & Harrison, F (2013) Selflessness is sexy: reported helping behaviour increases desirability of men and women as long-term sexual partners. BMC Evolutionary Biology 13:182.(From publisher, OA). This article got a lot of media attention, including from the Independent, Men's Health, the Daily Mail and BBC Radio Nottingham. I presented a partial version of this dataset at an ASAB conference and it was picked up by BBC South Today and Marie Claire magazine.
Harrison, F (2013) Dynamic social behaviour in a bacterium: Pseudomonas aeruginosa partially compensates for siderophore loss to cheats. Journal of Evolutionary Biology 26:1370-1378. (From publisher) (Data archived in Dryad, DOI:10.5061/dryad.t77nc). See also this comment from Samuel Alizon, and my response.
Harrison, F (2013) Bacterial cooperation in the wild and in the clinic: are pathogen social behaviours relevant outside the laboratory? BioEssays 35:108-112. (invited review and one of the highlights for the Feb 2013 issue) (From publisher, OA)
Scanlan, PD, Buckling, A, Kong, W, Wild, Y, Lynch, SV & Harrison, F (2012) Gut dysbiosis in cystic fibrosis. Journal of Cystic Fibrosis 11:454-455 (From ScienceDirect) (Free PDF)
Harrison, F & El Mouden, C (2011) Exploring the effects of working for endowments on behaviour in standard economic games PLoS ONE 6: e27623 (From publisher, OA)
Harrison, F, Sciberras, J & James, R (2011) Strength of social tie predicts cooperative investment in a human social network PLoS ONE 6:e18338 (From publisher, OA), also picked up by the Daily Mail. See also this article that James Sciberras wrote for the student science website Experimentation.
Harrison, F & Buckling, A (2011) Wider access to genotypic space facilitates loss of cooperation in a bacterial mutator PLoS ONE 6:e17254 (From publisher, OA)
Harrison, F (2011) Getting started with meta-analysis Methods in Ecology & Evolution 2:1-10 (From publisher, OA), also discussed in this podcast & included in MEE's June 2014 virtual issue Top Methods in Ecology and Evolution.
Racey, D, Inglis, R Fredrik, Harrison, F, Oliver, A & Buckling, A (2010) The effect of elevated mutation rates on cooperation and virulence of Pseudomonas aeruginosa Evolution 64:515-521 (From publisher)
Kümmerli, R, Griffin, A, West, SA, Buckling, A & Harrison, F (2009) Viscous medium promotes cooperation in the pathogenic bacterium Pseudomonas aeruginosa Proceedings: Biological Sciences 276:3531-3538(From publisher)(Free PDF)(Media: TalentScotland article)(Media: Compute Scotland)
Harrison, F, Barta, Z, C uthill, IC & Székely, T (2009) How is sexual conflict over parental care resolved? A meta-analysis Journal of Evolutionary Biology 22:1800-1812 (editor's pick for September 09 issue of JEB) (From publisher)(Media: Metro)(Media: Baby Hampshire Magazine)(Media: Origo.hu)(Media: blogged)
Harrison, F & Buckling, A (2009) Siderophore production and biofilm formation as linked social traits ISME Journal 3:632-634(From publisher)
Harrison, F & Buckling, A (2009) Siderophore cooperation in Pseudomonas aeruginosa Frontiers in Bioscience S1:250-263 (Invited review) (From publisher) (Free PDF)
Harrison, F, Paul, J, Massey, RC & Buckling, A (2008) Inter-specific competition and siderophore-mediated cooperation in Pseudomonas aeruginosa ISME Journal 2:49-55 (From publisher) (Free PDF)
Buckling, A, Harrison, F, Vos, M, Brockhurst, MA, Gardner, A, West, SA & Griffin, A (2007) Siderophore-mediated cooperation and virulence in Pseudomonas aeruginosa FEMS Microbiology Ecology 62(2):135-41 (From publisher)
Harrison, F (2007) Microbial ecology of the cystic fibrosis lung (Minireview) Microbiology 153(4):917-23 (From publisher) (Free PDF)
Harrison, F & Buckling, A (2007) High relatedness selects against hypermutability in bacterial metapopulations Proceedings: Biological Sciences 274(1615):1341-47 (From publisher) (Free PDF)
Harrison, F, Browning, LE, Vos, M & Buckling, A (2006) Cooperation and virulence in acute Pseudomonas aeruginosa infections BMC Biology 4(1):21 (From publisher, OA)
Harrison, F & Buckling, A (2005) Hypermutability impedes cooperation in pathogenic bacteria Current Biology 15(21):1968-71 (From ScienceDirect)
Articles marked OA are open access and may be freely viewed at the publisher's website. Other articles require a subscription to view at the publisher; OA versions of these articles are available either as pre-prints on bioRxiv (2016 onwards) or via a link marked 'Free PDF' (provided according to the terms of each publisher's copyright agreement - most are non-typeset versions of the accepted article).
Paramalingam Y, Arjmandi H, Harrison F, Schiller T, Noel A (preprint) Anisotropic diffusion model of communication in 2D biofilm. arXiv. doi.org/10.48550/arXiv.2408.07626
Piazza AM, Dasanayaka H, Martins C, Saalbach G, Trampari E, Webber M, Harrison F, Malone J (submitted) BatR: A novel regulator of antibiotic tolerance in Pseudomonas aeruginosa biofilms. bioRxiv 2024.04.17.589660 DOI: https://doi.org/10.1101/2024.04.17.589660
Simm C, Lee T-H, Weerasinghe H, Walsh D, Nakou I, Shankar M, Tse WC, Zhang Y, Inman R, Mulder R, Harrison F, Aguilar M-I, Challis G, Traven A (in press) Gladiolin produced by pathogenic Burkholderia synergizes with amphotericin B through membrane lipid rearrangements. Accepted for publication in mBio
Walsh D, Parmenter C, Bakker SE, Lithgow T, Traven A, Harrison F (2024) A new model of endotracheal tube biofilm identifies combinations of matrix-degrading enzymes and antimicrobials able to eradicate biofilms of pathogens that cause ventilator-associated pneumonia. Microbiology 170:001480 (From publisher, OA)
Walsh, D, Bevan, J, Harrison, F (2024) How does airway surface liquid composition vary in different pulmonary diseases, and how can we use this knowledge to model microbial infections? Microorganisms 12:732 (From publisher, OA)
Darby EM, Moran RA, Holden E, Morris T, Harrison F, Clough B, McInnes RS, Schneider L, Frickel EM, Webber MA, Blair JMA (2024) Differential development of antibiotic resistance and virulence between Acinetobacter species. mSphere 9:e00109-24 (From publisher, OA)
Concilio M, Garcia Maset R, Pasquina Lemonche L, Kontrimas V, Song J-I, Rajendrakumar SK, Harrison F, Becer R & Perrier S (2023) Mechanism of action of oxazoline-based antimicrobial polymers against S. aureus: in vivo antimicrobial activity evaluation. Advanced Healthcare Materials 2023:2301961 (From publisher, OA)
Harrison F, Blower A, de Wolf C & Connelly E (2023) Sweet and sour synergy: exploring the antibacterial and antibiofilm activity of acetic acid and vinegar combined with medical-grade honeys. Microbiology 169:001351 (From publisher, OA) (Article in The Times)(Article in the New York Post)(Article in Scientific American)(Podcast from Drug Discovery News)
Garcia Maset R, Hapeshi A, Lapage J, Harrington Niamh E, Littler Jenny L, Perrier S & Harrison, F (2023) Combining SNAPs with antibiotics shows enhanced synergistic efficacy against S. aureus and P. aeruginosa biofilms. npj Biofilms and Microbiomes. 9:36 (From publisher, OA)
Bruce J, Oyedemi B, Parsons N & Harrison F (2022) Phase 1 safety trial of a natural product cocktail with antibacterial activity in human volunteers. Scientific Reports. 12:19656. DOI: 10.1038/s41598-022-22700-4 (From publisher, OA)
Harrington, NE, Allen, F, Garcia Maset, R & Harrison, F (2022) Pseudomonas aeruginosa transcriptome analysis in a cystic fibrosis lung model reveals metabolic changes accompanying biofilm maturation and increased antibiotic tolerance over time. bioRxiv 2022.06.30.498312 (preprint)
Garcia Maset, R, Hapeshi, A, Hall, S, Dalgliesh, R, Harrison, F & Perrier, S (2022) Evaluation of the antimicrobial activity in host-mimicking media and in vivo toxicity of antimicrobial polymers as functional mimics of AMPs. ACS Applied Materials & Interfaces 14:32855 (From publisher, OA)
Harrison F, Furner-Pardoe J, Connelly E (2022) An assessment of the evidence for antibacterial activity of stinging nettle (Urtica dioica) extracts. Access Microbiology 4:000336 (From publisher, OA)
Harrington, NE, Littler, JL & Harrison, F (2022) Transcriptome analysis of Pseudomonas aeruginosa biofilm infection in an ex vivo pig model of the cystic fibrosis lung. Applied and Environmental Microbiology 88:e01789-21 (From publisher, OA)
O’Toole GA, Crabbé A, Kümmerli R, LiPuma JJ, Bomberger JM, Davies JC, Limoli D, Phelan VV, Bliska JB, DePas WH, Dietrich LE, Hampton TH, Hunter R, Khursigara CM, Price-Whelan A, Ashare A, Cramer RA, Goldberg JB, Harrison F, Hogan DA, Henson MA, Madden DR, Mayers JR, Nadell C, Newman D, Prince A, Rivett DW, Schwartzman JD, Schultz D, Sheppard DC, Smyth AR, Spero MA, Stanton BA, Turner PE, Gast Cvd, Whelan FJ, Whitaker R, Whiteson K. (2021) Model systems to study the chronic, polymicrobial infections in cystic fibrosis: current approaches and exploring future directions. mBio. 12:e01763-21 (From publisher, OA)
O'Brien, TJ, Hassan, MM, Harrison, F & Welch M. (2021) An in vitro model for the cultivation of polymicrobial biofilms under continuous-flow conditions. F1000Research 10:801 DOI: doi.org/10.12688/f1000research.55140.1 (From publisher, OA)
Harrington, NE, Sweeney, E, Alav, I, Allen, F, Moat, J & Harrison, F (2021) Antibiotic efficacy testing in an ex vivo model of Pseudomonas aeruginosa and Staphylococcus aureus biofilms in the cystic fibrosis lung. Journal of Visuaized Experiments 167:e62187. (From publisher, OA)
Harrison, F & Smyth, AR (2021) Professor Pangloss and the pangenome: Does Staphylococcus aureus have the best of all possible worlds? American Journal of Respiratory and Critical Care Medicine, AOP. (From publisher, OA)
Sweeney, E, Hassan, MM, Harrington, NE, Smyth, AR, Hurley, MN, Tormo-Mas, MA & Harrison, F (2021) An ex vivo cystic fibrosis model recapitulates key clinical aspects of chronic Staphylococcus aureus infection. Microbiology 167:000987 (From publisher, OA; Conference poster published in Access Microbiology, OA) Editor's choice for this issue of Microbiology!
Sweeney, E, Sabnis, A, Edwards, AM & Harrison, F (2020) Effect of host-mimicking medium and biofilm growth on the ability of colistin to kill Pseudomonas aeruginosa. Microbiology 166:1171 (From publisher, OA) Editor's choice for this issue of Microbiology!
Anonye, BO, Nweke, V, Furner-Pardoe, J, Gabrilska, R, Rafiq, A, Ukachukwu, F, Bruce, J, Lee, C, Unnikrishnan, M, Rumbaugh, KP, Snyder, LA & Harrison, F (2020) The safety profile of Bald's eyesalve for the treatment of bacterial infections. Scientific Reports 10:17513 (From publisher, OA)
Hassan, MM, Harrington, NE, Sweeney, E & Harrison, F (2020) Predicting antibiotic-associated virulence of Pseudomonas aeruginosa using an ex-vivo lung biofilm model. Frontiers in Microbiology 11:2175 (From publisher, OA)
Furner-Pardoe, J, Anonye, BO, Cain, R, Moat, J, Ortori, CA, Lee, C, Barrett, DA, Corre, C & Harrison, F (2020) Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients. Scientific Reports 10:12687 (From publisher, OA)
[Conference poster] Crealock-Ashurst, B, Harrison, F & Sweeney, E (2020) Assessing acute and chronic Staphylococcus aureus growth and virulence in an ex vivo model of cystic fibrosis lung infection. Access Microbiology 2:255 (From publisher, OA)
Harrington, NE, Sweeney, E & Harrison, F (2020) Building a better biofilm - formation of in vivo-like biofilm structures by Pseudomonas aeruginosa in a porcine model of cystic fibrosis lung infection. Biofilm 2:100024 (From publisher, OA)
Connelly, E, del Genio, CI & Harrison, F (2020) Datamining a medieval medical text reveals patterns in ingredient choice that reflect biological activity against the causative agents of specified infections. mBio 11:e03136-19 (From publisher, OA)
Harrison, F & Connelly, E (2019) Could Medieval Medicine Help the Fight Against Antimicrobial Resistance? In Chris Jones, Conor Kostick, Klaus Oschema (eds.), Making the Medieval Relevant: How Medieval Studies Contribute to Improving our Understanding of the Present (pp. 113–134). Berlin, Boston: De Gruyter. (From publisher, OA)
Brockhurst, MA, Harrison, F, Veening, J-W, Harrison, E, Blackwell, G, Iqbal, Z & Maclean, C (2019) Assessing evolutionary risks of resistance for new antimicrobial therapies. Nature Ecology & Evolution 3:515 (From publisher) (ReadCube, OA)
Chen, F, Moat, J, Daniel McFeely, D, Clarkson, G, Hands-Portman, IJ, Furner-Pardoe, JP, Harrison, F, Dowson, CG & Sadler, PJ (2018) Biguanide complexes with potent antimicrobial activity. Journal of Medicinal Chemistry 61:7330 (From publisher, OA)
Davies, SK, Fearn, S, Allsopp, LP, Harrison, F, Ware, E, Diggle, SP, Filloux, A, McPhail, DS & Bundy, JG (2017) Visualizing antimicrobials in bacterial biofilms: three-dimensional biochemical imaging using TOF-SIMS. mSphere, 2017. 2:e00211-17 (From publisher, OA)
Harrison, F, McNally, A, da Silva, AC, Heeb, S & Diggle, SP (2017) Optimised chronic infection models demonstrate that siderophore “cheating” in Pseudomonas aeruginosa is context specific. ISME Journal 11:2492 (From publisher, OA)
Mund, A, Diggle, SP & Harrison, F (2017) The fitness of Pseudomonas aeruginosa quorum sensing signal cheats is influenced by the diffusivity of the environment. mBio 8:00353-17 (From publisher, OA)
Popat, R, Harrison, F, McNally, L, Williams, P & Diggle, SP (2017) Environmental modification via a quorum sensing molecule influences the social landscape of siderophore production. Proceedings B 284:20170200 (From publisher, OA)
Granato, ET, Harrison, F, Kümmerli, R & Ross-Gillespie, A (2016) When is a bacterial "virulence factor" really virulent? Frontiers in Microbiology 7:1952 (From publisher, OA)
Harrison, F & Diggle, SP (2016) An ex vivo lung model to study bronchioles infected with Pseudomonas aeruginosa biofilms. Microbiology 162:1755 (From publisher)
Ruparell, A, Dubern, JF, Ortori, CA, Harrison, F, Halliday, NM, Emtage, A, Ashawesh, M, Laughton, CA, Diggle, SP, Williams, P, Barrett, DA & Hardie, KR (2016) The fitness burden imposed by synthesising quorum sensing signals. Scientific Reports 6:33101. (From publisher, OA)
Harrison, F, Roberts, AEL, Rumbaugh, KP, Gabrilska, R, Lee, C & Diggle, SP (2015) A 1,000-year-old antimicrobial remedy with anti-Staphylococcal activity. mBio 6:e01129-15. (From publisher, OA). This work received a huge amount of press attention when I spoke about it at an SGM conference in spring 2015, including features on BBC Radio 4's Today and on Sky News. Some of my favourite print articles came courtesy of New Scientist, National Geographic, medievalists.net and the Science Viking blog.
Popat, R, Pollitt, EJG, Harrison, F, Naghra, H, Hong, K-W, Chan, K-G, Griffin, AS, Williams, P, Brown, SP, West, SA & Diggle, SP (2015) Conflict of interest and signal interference lead to the breakdown of honest signalling. Evolution 69:2371. (From publisher, OA)
Darch, SE, McNally, A, Harrison, F, Corander, J, Barr, HL, Paszkiewicz, K, Holden, S, Fogarty, A, Crusz, SA & Diggle, SP (2015) Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection. Nature Scientific Reports 5:7649. (From publisher, OA)
Pollitt, EJG, Harrison, F & Diggle, SP (2015) Quorum sensing and social interactions during infection Microbe 10:17 (From Publisher)
Haddad, ADM, Harrison, F, Norman, T & Lau, JYF (2014) Adolescent and adult risk-taking in virtual social contexts. Frontiers in Psychology 5:1476 (From Publisher)
Harrison, F, Muruli, A, Higgins, S & Diggle, S (2014) Development of an ex vivo porcine lung model for studying growth, virulence and signalling of Pseudomonas aeruginosa. Infection and Immunity 82:3312. (From publisher, OA)
Barta, Z, Székely, T, Liker, A & Harrison, F (2014) Social role specialisation promotes cooperation between parents. American Naturalist 183:747. (From publisher, OA). I gave a talk about this work at the 2013 ESEB meeting, which you can watch on YouTube.
Moore, D, Wigby, S, English, S, Wong, S, Székely, T & Harrison, F (2013) Selflessness is sexy: reported helping behaviour increases desirability of men and women as long-term sexual partners. BMC Evolutionary Biology 13:182.(From publisher, OA). This article got a lot of media attention, including from the Independent, Men's Health, the Daily Mail and BBC Radio Nottingham. I presented a partial version of this dataset at an ASAB conference and it was picked up by BBC South Today and Marie Claire magazine.
Harrison, F (2013) Dynamic social behaviour in a bacterium: Pseudomonas aeruginosa partially compensates for siderophore loss to cheats. Journal of Evolutionary Biology 26:1370-1378. (From publisher) (Data archived in Dryad, DOI:10.5061/dryad.t77nc). See also this comment from Samuel Alizon, and my response.
Harrison, F (2013) Bacterial cooperation in the wild and in the clinic: are pathogen social behaviours relevant outside the laboratory? BioEssays 35:108-112. (invited review and one of the highlights for the Feb 2013 issue) (From publisher, OA)
Scanlan, PD, Buckling, A, Kong, W, Wild, Y, Lynch, SV & Harrison, F (2012) Gut dysbiosis in cystic fibrosis. Journal of Cystic Fibrosis 11:454-455 (From ScienceDirect) (Free PDF)
Harrison, F & El Mouden, C (2011) Exploring the effects of working for endowments on behaviour in standard economic games PLoS ONE 6: e27623 (From publisher, OA)
Harrison, F, Sciberras, J & James, R (2011) Strength of social tie predicts cooperative investment in a human social network PLoS ONE 6:e18338 (From publisher, OA), also picked up by the Daily Mail. See also this article that James Sciberras wrote for the student science website Experimentation.
Harrison, F & Buckling, A (2011) Wider access to genotypic space facilitates loss of cooperation in a bacterial mutator PLoS ONE 6:e17254 (From publisher, OA)
Harrison, F (2011) Getting started with meta-analysis Methods in Ecology & Evolution 2:1-10 (From publisher, OA), also discussed in this podcast & included in MEE's June 2014 virtual issue Top Methods in Ecology and Evolution.
Racey, D, Inglis, R Fredrik, Harrison, F, Oliver, A & Buckling, A (2010) The effect of elevated mutation rates on cooperation and virulence of Pseudomonas aeruginosa Evolution 64:515-521 (From publisher)
Kümmerli, R, Griffin, A, West, SA, Buckling, A & Harrison, F (2009) Viscous medium promotes cooperation in the pathogenic bacterium Pseudomonas aeruginosa Proceedings: Biological Sciences 276:3531-3538(From publisher)(Free PDF)(Media: TalentScotland article)(Media: Compute Scotland)
Harrison, F, Barta, Z, C uthill, IC & Székely, T (2009) How is sexual conflict over parental care resolved? A meta-analysis Journal of Evolutionary Biology 22:1800-1812 (editor's pick for September 09 issue of JEB) (From publisher)(Media: Metro)(Media: Baby Hampshire Magazine)(Media: Origo.hu)(Media: blogged)
Harrison, F & Buckling, A (2009) Siderophore production and biofilm formation as linked social traits ISME Journal 3:632-634(From publisher)
Harrison, F & Buckling, A (2009) Siderophore cooperation in Pseudomonas aeruginosa Frontiers in Bioscience S1:250-263 (Invited review) (From publisher) (Free PDF)
Harrison, F, Paul, J, Massey, RC & Buckling, A (2008) Inter-specific competition and siderophore-mediated cooperation in Pseudomonas aeruginosa ISME Journal 2:49-55 (From publisher) (Free PDF)
Buckling, A, Harrison, F, Vos, M, Brockhurst, MA, Gardner, A, West, SA & Griffin, A (2007) Siderophore-mediated cooperation and virulence in Pseudomonas aeruginosa FEMS Microbiology Ecology 62(2):135-41 (From publisher)
Harrison, F (2007) Microbial ecology of the cystic fibrosis lung (Minireview) Microbiology 153(4):917-23 (From publisher) (Free PDF)
Harrison, F & Buckling, A (2007) High relatedness selects against hypermutability in bacterial metapopulations Proceedings: Biological Sciences 274(1615):1341-47 (From publisher) (Free PDF)
Harrison, F, Browning, LE, Vos, M & Buckling, A (2006) Cooperation and virulence in acute Pseudomonas aeruginosa infections BMC Biology 4(1):21 (From publisher, OA)
Harrison, F & Buckling, A (2005) Hypermutability impedes cooperation in pathogenic bacteria Current Biology 15(21):1968-71 (From ScienceDirect)
